Stephen Hawking Dead At 76, Leaving Behind A Science And Pop Culture Legacy

The world has lost one of its greatest minds.

Stephen Hawking, the renowned theoretical physicist who helped shape current thought on cosmology and the infinite possibilities of the universe, has died. He was 76.

Hawking died in his home in Cambridge, U.K., early Wednesday morning, his family confirmed in a statement (via New York Times).

In a statement his family said:

"We are deeply saddened that our beloved father passed away today. He was a great scientist and an extraordinary man whose work and legacy will live on for many years. His courage and persistence with his brilliance and humor inspired people across the world. He once said, 'It would not be much of a universe if it wasn't home to the people you love.' We will miss him forever."

Hawking was best known for his acclaimed 1988 cosmology book A Brief History of Time, which pondered the origin and fate of the universe as well as theories about space and time travel. A Brief History of Time stayed on the Sunday Times of London's best-sellers list for an unprecedented 237 weeks, selling 10 million copies worldwide. It helped launch him to fame as one of the foremost scientists of our times.

Born in 1942 in Oxford, England, the brilliant physicist was diagnosed with ALS, a neurodegenerative disease, in 1963. Doctors at the time gave him a life expectancy of only two years, but Hawking would go on to live for 55 more years.

The disease slowly paralyzed his body and motor functions. But the advent of a motorized wheelchair and synthesized computer vocalizations in the 1980s allowed Hawking to communicate, and his image became synonymous with the tools he employed.

Hawking's unique and inspirational struggle against ALS as well as his groundbreaking theories were depicted in the award-winning 2014 biopic The Theory of Everything. Eddie Redmayne won an Oscar for his portrayal of Hawking in the feature film based off the memoir by Hawking's first wife, Jane Hawking. Benedict Cumberbatch also won a BAFTA for playing the scientist in the BBC TV film Hawking.

But those adaptations were not the only lasting influence that Hawking left behind on pop culture.

"The Simpsons is the best thing on American television," the late astrophysicist said on BBC's The Culture Show after his cameo on the hit animated series in 1999.

Hawking appeared in the episode "They Saved Lisa's Brain" in 1999, saving Springfield from its crumbling utopian meritocracy. His appearance was so memorable that many people thought he was a character invented for the show. Hawking would go on to make three more appearances in The Simpsons, including an cameo where he trades barbs with the Flight of the Conchords stars. He also made several cameos on Futurama.

Pink Floyd sampled Hawking's voice in a track from the band's 1994 album, "The Division Bell." The sample was taken from a 1993 TV commercial for British telephone company BT. Pink Floyd would use another clip of Hawking's unique synthesized voice in the 2014 track "Talkin' Hawkin'" on their final studio album "The Endless River."

One of Hawking's most beloved comedic appearances was his sit-down with British comedy host John Oliver on his "People Who Think Good" segment. The bit features Hawking tearing into Oliver, after the host asks, "You've stated there could be an infinite number of parallel universes. Does that mean that there is a universe out there where I am smarter than you?"

"Yes," Hawking shot back. "And also a universe where you're funny."