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Natalie Portman has developed a pretty good ‘four for me, one for them’ approach to picking roles, with V for Vendetta, Mr. Magorium’s Wonder Emporium and Thor being her big studio films since escaping the Star Wars prequels, and many an indie or picture in between. Her production company Handsome Charlie Films has got movies like Hesher and Pride and Prejudice and Zombies coming down the pipe, confirming her dedicated indie approach to filmmaking. Not sure where a stoner road trip comedy fits in, but one is now reportedly on the slate as well, as Portman will produce and star in a weed-oriented film called Best Buds.

Pajiba has the news about the film, which is based on a script by actress Jamie Denbo. The plot follows “two best female friends who take a road trip to their friend’s wedding in order to save her by bringing her weed.” No word yet on who’ll direct and who’ll play the other friend. (Probably not Denbo, who has appeared in the pilot for Ronna & Beverly and Weeds, though maybe she’ll play the friend who is getting married.) More important, there aren’t yet details on what’s really in the script that makes it interesting. I can deal with the stoner comedy (Pineapple Express: good, Land of the Lost: better) but expect there’s a bit more going on here. Or maybe not: the script is said to be along the lines of Harold & Kumar and Half Baked.

Portman has long since wrapped Your Highness, the high-concept, medieval-set David Gordon Green comedy that has ’80s fantasy movie references and some vague stoner underpinning. (Portman is co-starring there with James Franco, Danny McBride and Zooey Deschanel.) That’ll be out this year, as will (hopefully) Black Swan, the Darren Aronofsky film that also recently wrapped.

(Speaking of Pineapple Express, James Franco says “practical steps are being taken” to make a sequel happen, whatever that means.)

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