However, this isn't the first time a Marvel movie has used the song, as it also appears in "X2: X-Men United" when Wolverine, Rogue, Pyro, and Iceman escape the X-Mansion.
As they drive away, Pyro decides to play some music to fill the awkward silence, and the first song is NSYNC's "Bye Bye Bye." The others give a collective groan at the song.